Background: Infant hepatitis B infection increases risk of chronic infection, cirrhosis or liver cancer (hepatocellular carcinoma) in adult. Perinatal transmission is a common route of infection.Objectives: To assess the effectiveness and adverse effects of hepatitis B vaccine administered to pregnant women for preventing hepatitis B virus infection in infants.Search methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010).Selection criteria: Randomized controlled trials (RCTs) assessing hepatitis B vaccination compared with placebo or no treatment during pregnancy for preventing infant infection. We excluded quasi‚ÄêRCTs and crossover studies.Data collection and analysis: Two review authors independently assessed trial eligibility.Main results: We were not able to include any studies.Authors' conclusions: We found no RCTs that assessed the effects of hepatitis B vaccine during pregnancy for preventing infant infection. Consequently, this review cannot provide guidance for clinical practice in this area. However, it does identify the need for well‚Äêdesigned randomized clinical trials for the effect of hepatitis B vaccine during pregnancy on the incidence of infant infection and adverse effects.
CITATION STYLE
Sangkomkamhang, U. S., Lumbiganon, P., & Laopaiboon, M. (2011). Hepatitis B vaccination during pregnancy for preventing infant infection. In Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd. https://doi.org/10.1002/14651858.cd007879.pub2
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