Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract

Abstract

Background: Epithelial-mesenchymal transition (EMT) helps solid tumors to lose their intercellular adhesive property and drives metastasis. As mangosteen fruit is known for many beneficial effects including antimicrobial, antioxidant, and anti-tumorigenic properties and has been used widely in traditional medicine, we interrogated its possible antimetastatic effect on MCF-7 breast cancer cells. Results: We found that aqueous mangosteen rind extract (MRE) inhibited growth of MCF-7 and altered the transcript levels of ERa, ERP, and EGFR genes. Additionally, the MRE changed the expression of important markers of EMT, E-Cadherin, N-Cadherin, Snail, and MMP-9. Moreover, MRE inhibited migration of MCF-7 cells. Conclusion: The results suggest that MRE suppresses growth and inhibits epithelial-mesenchymal transition in MCF-7 cells.