Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media

Ikuo Nakanishi; Kei Ohkubo; Kohei Imai; Masato Kamibayashi; Yasuo Yoshihashi; Ken Ichiro Matsumoto; Kiyoshi Fukuhara; Katsuhide Terada; Shinobu Itoh; Toshihiko Ozawa; Shunichi Fukuzumi

Journal ArticleOPEN ACCESS

Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media

Nakanishi I
Ohkubo K
Imai K
et al.

Chemical Communications (2015) 51(39) 8311-8314

DOI: 10.1039/c5cc02236c

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Abstract

A 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) was successfully solubilised in water by β-cyclodextrin (β-CD). DPPH/β-CD thus obtained was demonstrated to be a powerful tool to evaluate the antioxidative activity of water-soluble antioxidants, such as ascorbate and Trolox, in aqueous buffer solutions.

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Nakanishi, I., Ohkubo, K., Imai, K., Kamibayashi, M., Yoshihashi, Y., Matsumoto, K. I., … Fukuzumi, S. (2015). Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media. Chemical Communications, 51(39), 8311–8314. https://doi.org/10.1039/c5cc02236c

Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media

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