Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury

13Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Recently, arginase is suggested to regulate nitric oxide production by competing with nitric oxide synthase for the same substrate, L-arginine, in experimental asthma. We investigated the role of arginase and its relationship to nitric oxide production after spinal cord injury. Rats were subjected to laminectomy and complete transection of their spinal cords (injury group) or laminectomy only (sham group). In the injury group, arginase I was increased in the macrophages at the transection edge, and the peak was observed 48 h after spinal cord injury. However, nitric oxide production decreased significantly in the injury group despite increased nitric oxide synthase2 mRNA expression compared with the sham group. We also demonstrated the reduction in L-arginine concentrations, which was inversely associated with changes in arginase activity. Therefore, arginase appeared to regulate nitric oxide production by consuming L-arginine. The regulation of arginase activity and L-arginine levels may improve nitroxidative stress and reduce tissue damage in spinal cord injury. ©2012 JCBN.

Cite

CITATION STYLE

APA

Imagama, T., Ogino, K., Takemoto, K., Kato, Y., Kataoka, H., Suzuki, H., … Taguchi, T. (2012). Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury. Journal of Clinical Biochemistry and Nutrition, 51(1), 68–75. https://doi.org/10.3164/jcbn.D-11-00011

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free