Induction of BALT in the absence of IL-17

Abstract

They have presented data showing that both CXCL13 expression and iBALT formation can occur independently of IL-17A and IL-17F after infection with MVA. Thus, they conclude that IL-17 is not required for either iBALT formation or CXCL13 expression in the lungs. In contrast, our data have shown that repeated pulmonary administration of LPS to neonatal mice promotes iBALT formation and that this process is dependent on both IL-17R and IL-17A.