Facile synthesis of novel spiroheterocycles via diastereoselective aziridination of cyclic enones

Abstract

A collection of novel spiroheterocycles with strained aziridine moieties have been facilely synthesized by using easily accessible starting materials under mild reaction conditions. This procedure is robust, scalable and highly diastereoselective, and also features broad substrate scope. In addition, some of the products show promising in vitro biological activity against a spectrum of pathogens, which might be considered as a clue for the discovery of new antimicrobial agents.