Stereoselective synthesis of ferrocene-based C2-symmetric diphosphine ligands: Application to the highly enantioselective hydrogenation of α-substituted cinnamic acids

Abstract

(Chemical Equation Presented) Chirality3: A new ferrocene-based diphosphine ligand is applied to the asymmetric hydrogenation of α-substituted cinnamic acids. The P-centered-, C-centered-, and planar-chiral ligand (RC,RC,SFc,S Fc,SP,SP)-1 displays unprecedented enantioselectivity in this Rh-catalyzed reaction (see scheme; cod = cycloocta-1,5-diene). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.