The essential membrane complex FtsE/FtsX (FtsEX), belonging to the ABC transporter superfamily and widespread among bacteria, plays a relevant function in some crucial cell wall remodeling processes such as cell division, elongation, or sporulation. FtsEX plays a double role by recruiting proteins to the divisome apparatus and by regulating lytic activity of the cell wall hydrolases required for daughter cell separation. Interestingly, FtsEX does not act as a transporter but uses the ATPase activity of FtsE to mechanically transmit a signal from the cytosol, through the membrane, to the periplasm that activates the attached hydrolases. While the complete molecular details of such mechanism are not yet known, evidence has been recently reported that clarify essential aspects of this complex system. In this chapter we will present recent structural advances on this topic. The three-dimensional structure of FtsE, FtsX, and some of the lytic enzymes or their cognate regulators revealed an unexpected scenario in which a delicate set of intermolecular interactions, conserved among different bacterial genera, could be at the core of this regulatory mechanism providing exquisite control in both space and time of this central process to assist bacterial survival.
CITATION STYLE
Alcorlo, M., Martínez-Caballero, S., Molina, R., & Hermoso, J. A. (2022). Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome. In Subcellular Biochemistry (Vol. 99, pp. 285–315). Springer Science and Business Media B.V. https://doi.org/10.1007/978-3-031-00793-4_9
Mendeley helps you to discover research relevant for your work.