The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination

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Abstract

The experience of pain is generated by activations throughout a complex pain network with the insular cortex as a central processing area. The state of ongoing oscillatory activity can influence subsequent processing throughout this network. In particular the ongoing theta-band power can be relevant for later pain processing, however a direct functional relation to post-stimulus processing or behaviour is missing. Here, we used a non-invasive brain–computer interface to either increase or decrease ongoing theta-band power originating in the insular cortex. Our results show a differential modulation of oscillatory power and even more important a transfer to independently measured pain processing and sensation. Pain evoked neural power and subjective pain discrimination were differentially affected by the induced modulations of the oscillatory state. The results demonstrate a functional relevance of insular based theta-band oscillatory states for the processing and subjective discrimination of nociceptive stimuli and offer the perspective for clinical applications.

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APA

Taesler, P., & Rose, M. (2021). The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-89206-3

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