Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs

  • Rajput C
  • Singhal S
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Abstract

A series of 3-[ 2 ′ -(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones ( 5–10 ), 3-[ 2 ′ -( 3 ″ -chloro- 2 ″ -oxo- 4 ″ -substitutedphenylazetidin- 1 ″ -yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones ( 11–16 ), and 3-[ 2 ′ -( 2 ″ -substitutedphenyl- 4 ″ -oxo- 1 ″ , 3 ″ -thiazolidin- 3 ″ -yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones ( 17–22 ) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H 1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic activities.

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Rajput, C. S., & Singhal, S. (2013). Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs. Journal of Pharmaceutics, 2013, 1–7. https://doi.org/10.1155/2013/907525

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