A model for the effect of homologous recombination on microbial diversification

19Citations
Citations of this article
52Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The effect of homologous recombination (HR) on the evolution of microbial genomes remains contentious as competing hypotheses seek to explain the evolutionary dynamics of microbial species. Evidence for HR between microbial genomes is widespread, and this process has been proposed to act as a cohesive force that can constrain the diversification of microbial lineages. We seek to characterize the evolutionary dynamics of sympatric populations to explore the impact of HR on microbial speciation. We describe a simple equation for quantifying the cohesive effect of HR on microbial populations as a function of their nucleotide divergence, μ/ρ=π g10 -20πg. The model was verified using a forward-time microbial population simulator that can explore the evolutionary dynamics of sympatric populations in nonoverlapping niche space. The model was also evaluated using multilocus sequence data from a range of microbial species, providing criteria for dividing them into either cohesively recombining or clonally diverging lineages. We conclude that models of microbial diversification that appear contradictory can be explained in a unified manner as the natural and predictable consequence of variation in a small number of population parameters. © The Author(s) 2010.

Cite

CITATION STYLE

APA

Doroghazi, J. R., & Buckley, D. H. (2011). A model for the effect of homologous recombination on microbial diversification. Genome Biology and Evolution, 3(1), 1349–1356. https://doi.org/10.1093/gbe/evr110

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free