Forkhead box transcription factors of the FOXA class are required for basal transcription of angiotensin- converting enzyme 2

17Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

Angiotensin-converting enzyme 2 (ACE2) has protective effects on a wide range of morbidities associated with elevated angiotensin-II signaling. Most tissues, including pancreatic islets, express ACE2 mainly from the proximal promoter region. We previously found that hepatocyte nuclear factors 1a and 1b stimulate ACE2 expression from three highly conserved hepatocyte nuclear factor 1 binding motifs in the proximal promoter region. We hypothesized that other highly conserved motifs would also affect ACE2 expression. By systematic mutation of conserved elements, we identified five regions affecting ACE2 expression, of which two regions bound transcriptional activators. One of these is a functional FOXA binding motif. We further identified the main protein binding the FOXA motif in 832/13 insulinoma cells as well as in mouse pancreatic islets as FOXA2.

Cite

CITATION STYLE

APA

Pedersen, K. B., Chodavarapu, H., & Lazartigues, E. (2017). Forkhead box transcription factors of the FOXA class are required for basal transcription of angiotensin- converting enzyme 2. Journal of the Endocrine Society, 1(4), 370–384. https://doi.org/10.1210/js.2016-1071

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free