To assess the incidence of and risk factors for clinical and subclinical dengue virus (DENV) infection, we prospectively studied 1,207 adult short-term travelers from the Netherlands to dengue-endemic areas. Participants donated blood samples for serologic testing before and after travel. Blood samples were tested for antibodies against DENV. Seroconversion occurred in 14 (1.2%) travelers at risk. The incidence rate was 14.6 per 1,000 person-months. The incidence rate was signifi cantly higher for travel during the rainy months. Dengue-like illness occurred in 5 of the 14 travelers who seroconverted. Seroconversion was signifi cantly related to fever, retroorbital pain, myalgia, arthralgia, and skin rash. The risk for DENV infection for short-term travelers to dengueendemic areas is substantial. The incidence rate for this study is comparable with that in 2 other serology-based prospective studies conducted in the 1990s.
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Baaten, G. G. G., Sonder, G. J. B., Zaaijer, H. L., van Gool, T., Kint, J. A. P. C. M., & van den Hoek, A. (2011). Travel-related dengue virus infection, the Netherlands, 2006-2007. Emerging Infectious Diseases, 17(5), 821–828. https://doi.org/10.3201/eid1705.101125