Background: The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure. Results: This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset. Conclusion: The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies. © 2009 Marco and Marín; licensee BioMed Central Ltd.
CITATION STYLE
Marco, A., & Marín, I. (2009). Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell. BMC Systems Biology, 3. https://doi.org/10.1186/1752-0509-3-69
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