Alternative polyadenylation is increasingly being recognized as an important layer of gene regulation. Antisense-mediated modulation of alternative polyadenylation represents an attractive strategy for the regulation of gene expression as well as potential therapeutic applications. In this chapter, we describe methods to upregulate the functional Kv11.1 isoform expression by blocking intronic polyadenylation signal sequences with antisense morpholinos.
CITATION STYLE
Gong, Q., & Zhou, Z. (2017). Regulation of isoform expression by blocking polyadenylation signal sequences with morpholinos. In Methods in Molecular Biology (Vol. 1565, pp. 141–150). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6817-6_12
Mendeley helps you to discover research relevant for your work.