Role of hemostatic risk factors for restenosis in peripheral arterial occlusive disease after transluminal angioplasty

Abstract

In a prospective study, the role of various hemostatic factors known to be associated with thrombotic risk was investigated in 71 patients with peripheral arterial occlusive disease (PAOD, stages II through IV, Fontaine; aged 68±13 years). Laboratory investigations were done before; 1, 24, and 48 hours after; and 3 and 6 months after percutaneous transluminal angioplasty (PTA). Thirty of 71 (42.3%) patients developed restenosis (>50% reduction of the lumen diameter) at the site of PTA within 6 months, verified by color- coded duplex sonography. Significantly increased levels of thrombin- antithrombin III complexes (P 2.8 g/L) or C-reactive protein at baseline was 2.80 (95% CI: 1.30-6.02, P