Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion

35Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.
Get full text

Abstract

We utilized a sample of 299 adult females aged between 19 and 86years, carrying fragile X mental retardation (FMR1) alleles with small CCG expansions ranging from 50 to 141 repeats to analyse the relationships between psychological symptoms as assessed by the Symptom Checklist-90-Revised (SCL-90-R) and the size of the CGG repeat in the FMR1 gene. There were highly significant (negative) correlations between the size of the CGG repeat and a great majority of SCL-90-R subscale scores and all the global indices, suggesting that carriers of premutations in the mid-size CGG repeat range may be at greatest risk for the development of psychiatric disorder.

Cite

CITATION STYLE

APA

Loesch, D. Z., Bui, M. Q., Hammersley, E., Schneider, A., Storey, E., Stimpson, P., … Hessl, D. (2015). Psychological status in female carriers of premutation FMR1 allele showing a complex relationship with the size of CGG expansion. Clinical Genetics, 87(2), 173–178. https://doi.org/10.1111/cge.12347

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free