Single isocenter stereotactic irradiation for multiple brain metastases: current situation and prospects

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Abstract

The prognosis of patients with brain metastases has dramatically improved, and long-term tumor control and reduction of the risk of late toxicities, including neurocognitive dysfunction, are important for patient quality of life. Stereotactic irradiation for multiple brain metastases, rather than whole-brain radiotherapy, can result in high local control rate with low incidence of neurocognitive deterioration and leukoencephalopathy. Recent advances in radiotherapy devices, treatment-planning systems, and image-guided radiotherapy can realize single isocenter stereotactic irradiation for multiple brain metastases (SI-STI-MBM), in which only one isocenter is sufficient to treat multiple brain metastases simultaneously. SI-STI-MBM has expanded the indications for linear accelerator-based stereotactic irradiation and considerably reduced patient burden. This review summarizes the background, methods, clinical outcomes, and specific consideration points of SI-STI-MBM. In addition, the prospects of SI-STI-MBM are addressed.

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APA

Uto, M., Torizuka, D., & Mizowaki, T. (2022, October 1). Single isocenter stereotactic irradiation for multiple brain metastases: current situation and prospects. Japanese Journal of Radiology. Springer. https://doi.org/10.1007/s11604-022-01333-7

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