Poly (riboflavin) modified pencil graphite for the simultaneous electrochemical determination of serotonin and dopamine

Abstract

A poly (riboflavin) modified pencil graphite electrode was fabricated by electropolymerization process. The fabricated electrode was characterized morphologically and electrochemically. Dopamine and serotonin was found to undergo irreversible electroxidation at potentials 0.103 V and 0.292 V respectively on the modified electrode surface in phosphate buffer saline pH 7.4. Also the potential of the developed electrode as a tool to determine the concentrations of serotonin and dopamine was also described. The sensor possesses a linear range of 1 μM - 320 μM. The efficiency of the sensor to be used in practical samples was tested using human serum samples.