Association of QnrB determinants and production of extended-spectrum β-lactamases or plasmid-mediated AmpC β-lactamases in clinical isolates of Klebsiella pneumoniae

Abstract

Clinical isolates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases or plasmid-mediated AmpC β-lactamases were screened for qnrA and qnrB genes. QnrB was present in 54 of 54 DHA-1-producing K. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distribution of plasmids conferring resistance to extended-spectrum cephalosporins and quinolones in clinical isolates of K. pneumoniae is widespread. Copyright © 2007, American Society for Microbiology. All Rights Reserved.