The clinical dose response to aspirin

Abstract

Summary: Graded doses of aspirin and a placebo were given to a total of 500 patients, in three hospitals, in an attempt to define the degree of precision and repeatability with which a dose-response relationship could be established. Evaluation of pain and relief was subjective, side effects were noted, and several approaches to statistical analysis of results were used. The investigation was divided into five separate studies; although a dose-response relationship emerged in each study there was considerable variation and the implications of this are discussed. © 1968 John Sherratt and Son Ltd.