NBR2: A former junk gene emerges as a key player in tumor suppression

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Abstract

NBR2 (neighbor of BRCA1 gene 2) is a non–protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate–activated protein kinase (AMPK) activation.

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Xiao, Z. D., Liu, X., Zhuang, L., & Gan, B. (2016). NBR2: A former junk gene emerges as a key player in tumor suppression. Molecular and Cellular Oncology, 3(4). https://doi.org/10.1080/23723556.2016.1187322

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