Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

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Abstract

Background. The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Methods. Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. Results. All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. Conclusions. The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.

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Dargelos, M., Couturier, A., Ferlicot, S., Goujon, J. M., Roque-Afonso, A. M., Gault, E., … Massy, Z. A. (2020). Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures. Clinical Kidney Journal, 13(6), 1101–1104. https://doi.org/10.1093/CKJ/SFAA209

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