Is the recommended dose of leflunomide the best regimen to treat rheumatoid arthritis patients? [10]

Abstract

In summary, in our series of rheumatoid arthritis patients treated with LFN, adverse events were frequent but in most cases the drug was well tolerated. There was no correlation between the loading dose and adverse events, but it is possible that a correlation exists between the loading dose and the occurrence of early serious adverse events. LFN is an effective treatment for the clinical control of rheumatoid arthritis and it is possible that the clinical efficacy in the long term is not influenced by the loading dose. Large prospective studies exploring new dose regimens are needed in order to improve the safety of this drug. A large number of patients may benefit from LFN if the dose is adjusted.