¿Hay relación entre los últimos brotes de tosferina y el uso de vacuna acelular?

Abstract

During the 1990s, in the U.S. UU. gradually replaced the vaccine with whole cell pertussis (DTPw) by acellular (DTPa), with fewer side effects. A case study and tests conducted in California, who studies the impact of vaccination on the incidence rate of pertussis (diagnosed by chain reaction polymerase Bordetella pertussis and B. parapertussis) in adolescents during an outbreak of the disease was evaluated in 2010. The results show that adolescents who received four doses of DTPw in the first two years of life were better protected against disease than those who had received four doses of DTaP. For those who received a mixed vaccine (DTPw and DTPa) there was a clear (linear and increasing) relationship between the number of doses of DTaP received and the likelihood of pertussis, a 40% increase in the risk of pertussis for each dose additional DTPa received. The generalization of acellular vaccines has been linked to the increasing emergence in recent years of outbreaks. Although the causes are undoubtedly more complex, the shorter duration of the protective effect of this vaccine appears to play an important role.