Suppressive effect of fucoidan derived from mozuku on in vitro invasion of human fibrosarcoma HT1080 cells

Abstract

Fucoidan is a uniquely-structured sulfated polysaccharides that is found in the cell walls of several types of brown seaweed, but not of land plants. Recently, Fucoidan has clin. got a lot attention due to its anti-tumor metastasis potential. We report here that the enzyme-digested fucoidan ext. derived from Cladosiphon novae-caledoniae kylin, which was called "mozuku" in the Kingdom of Tonga, inhibited in vitro invasion of human fibrosarcoma HT1080 cells. Flow cytometric anal. revealed that the enzyme-digested fucoidan ext. effectively scavenged intracellular H2O2 of HT1080 cells. Both activities of MMP2 and 9 were decreased in a dose dependent manner by the fucoidan ext., suggesting that Fucoidan may inhibit the invasion of tumor cells via suppression of MMP2 and 9 activities. [on SciFinder(R)]