Growth depression and tissue reaction to the consumption of excess dietary methionine and S methyl L cysteine

30Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Similar depressions in growth were observed when rats consumed a 10% casein basal diet containing equal quantities of either methionine or S methyl L cysteine. Supplemental glycine or serine partially alleviated the growth depression caused by the high levels of methionine but were ineffective in alleviating the growth depression caused by high levels of S methylcysteine. Histologic examination of 5 organs of rats fed the basal, high methionine or high S methylcysteine diet for 6, 13 or 20 days revealed that only the spleens were affected in that there was erythrocyte engorgement and an accumulation of hemosiderin. The intensity of iron staining in spleens decreased from the second to the third wk. The similarity in the depression of growth and splenic damage observed in rats consuming high levels of methionine or S methylcysteine is consistent with an earlier suggestion that metabolism of the methyl group is in some way involved in the toxicity of methionine.

Cite

CITATION STYLE

APA

Benevenga, N. J., Yeh, M. H., & Lalich, J. J. (1976). Growth depression and tissue reaction to the consumption of excess dietary methionine and S methyl L cysteine. Journal of Nutrition, 106(12), 1714–1720. https://doi.org/10.1093/jn/106.12.1715

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free