Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent studies found the absolute and relative decreases in circulating regulatory T cells (Tregs) in RA patients. Tregs are a unique type of cells exhibiting immunosuppressive functions, known for expressing the Foxp3 gene. They are instrumental in maintaining immunological tolerance and preventing autoimmunity. Increasing the absolute number and/or enhancing the function of Tregs are effective strategies for treating RA. This article reviews the studies on the mechanisms and targeted therapies related to Tregs in RA, with a view to provide better ideas for the treatment of RA.
CITATION STYLE
Zhang, J., Liu, H., Chen, Y., Liu, H., Zhang, S., Yin, G., & Xie, Q. (2024). Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis. Frontiers in Immunology. Frontiers Media SA. https://doi.org/10.3389/fimmu.2024.1312919
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