Plant NB-LRR proteins: Tightly regulated sensors in a complex manner

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Abstract

As plants are sessile, they have evolved hundreds of resistance (R) genes to defend themselves against multiple pathogens. Most of plant R genes encode proteins with the nucleotide-binding and leucine-rich repeat (NB-LRR) domains that interact with pathogen effectors to induce defense responses. Recent findings describing R proteins structures, host interactors and transcriptional and posttranscriptional regulators have broadened our understanding of R gene activity regulation. Genome-wide analyses of NB-LRR genes are useful for identifying host and nonhost R genes and elucidating complex resistance mechanisms. This review provides an overview of the functions of identified NB-LRRs and intra- and intermolecular R gene regulators.

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Lee, H. A., & Yeom, S. I. (2015). Plant NB-LRR proteins: Tightly regulated sensors in a complex manner. Briefings in Functional Genomics, 14(4), 233–242. https://doi.org/10.1093/bfgp/elv012

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