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A hybrid model of sprouting angiogenesis

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (2008) 5102 LNCS(PART 2) 167-176
DOI: 10.1007/978-3-540-69387-1_19
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Abstract

We present a computational model of tumor induced sprouting angiogenesis that involves a novel coupling of particle-continuum descriptions. The present 3D model of sprouting angiogenesis accounts for the effect of the extracellular matrix on capillary growth and considers both soluble and matrix-bound growth factors. The results of the simulations emphasize the role of the extracellular matrix and the different VEGF isoforms on branching behavior and the morphology of generated vascular networks. © 2008 Springer-Verlag Berlin Heidelberg.

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Milde, F., Bergdorf, M., & Koumoutsakos, P. (2008). A hybrid model of sprouting angiogenesis. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5102 LNCS, pp. 167–176). https://doi.org/10.1007/978-3-540-69387-1_19

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