Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila

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Abstract

A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3-4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1-4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines. © 2011 by the authors.

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Wang, C. C., Liu, H. Z., Liu, M., Zhang, Y. Y., Li, T. T., & Lin, X. K. (2011). Cytotoxic metabolites from the soil-derived fungus Exophiala pisciphila. Molecules, 16(4), 2796–2801. https://doi.org/10.3390/molecules16042796

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