Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance has been strongly implicated as a cause of disease. Thus, understanding tau isoform regional expression in disease and pathology-free states is crucial to elucidating the mechanisms involved in PSP and other tauopathies. We used a tau isoform-specific fluorescent assay to investigate relative 4R-tau expression in 6 different brain regions in PSP cases and healthy control samples. We identified a marked difference in 4R-tau relative expression, across brain regions and between MAPT haplotypes. Highest 4R-tau expression levels were identified in the globus pallidus compared with pons, cerebellum, and frontal cortex. 4R-tau expression levels were related to the MAPT H1 and H1c haplotypes. Similar regional variation was seen in PSP case and in control samples. © 2013 Elsevier Inc.
CITATION STYLE
Majounie, E., Cross, W., Newsway, V., Dillman, A., Vandrovcova, J., Morris, C. M., … Morris, H. R. (2013). Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging, 34(7), 1922.e7-1922.e12. https://doi.org/10.1016/j.neurobiolaging.2013.01.017
Mendeley helps you to discover research relevant for your work.