Olfactory optogenetics: Light illuminates the chemical sensing mechanisms of biological olfactory systems

3Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

The mammalian olfactory system has an amazing ability to distinguish thousands of odorant molecules at the trace level. Scientists have made great achievements on revealing the olfactory sensing mechanisms in decades; even though many issues need addressing. Optogenetics provides a novel technical approach to solve this dilemma by utilizing light to illuminate specific part of the olfactory system; which can be used in all corners of the olfactory system for revealing the olfactory mechanism. This article reviews the most recent advances in olfactory optogenetics devoted to elucidate the mechanisms of chemical sensing. It thus attempts to introduce olfactory optogenetics according to the structure of the olfactory system. It mainly includes the following aspects: the sensory input from the olfactory epithelium to the olfactory bulb; the influences of the olfactory bulb (OB) neuron activity patterns on olfactory perception; the regulation between the olfactory cortex and the olfactory bulb; and the neuromodulation participating in odor coding by dominating the olfactory bulb. Finally; current challenges and future development trends of olfactory optogenetics are proposed and discussed.

References Powered by Scopus

Millisecond-timescale, genetically targeted optical control of neural activity

3790Citations
N/AReaders
Get full text

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

2151Citations
N/AReaders
Get full text

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

1984Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Olfactory receptor-based biosensors as potential future tools in medical diagnosis

33Citations
N/AReaders
Get full text

Structural and functional features of the olfactory epithelium in fish

1Citations
N/AReaders
Get full text

Optic-Fiber-Based Optogenetic Stimulator With μLED and 3D-Printed Structures for Brain Stimulation

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zhu, P., Tian, Y., Chen, Y., Chen, W., Wang, P., Du, L., & Wu, C. (2021, September 1). Olfactory optogenetics: Light illuminates the chemical sensing mechanisms of biological olfactory systems. Biosensors. MDPI. https://doi.org/10.3390/bios11090309

Readers over time

‘21‘22‘23‘2402468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

50%

Researcher 3

38%

Professor / Associate Prof. 1

13%

Readers' Discipline

Tooltip

Neuroscience 3

43%

Agricultural and Biological Sciences 2

29%

Biochemistry, Genetics and Molecular Bi... 1

14%

Engineering 1

14%

Save time finding and organizing research with Mendeley

Sign up for free
0