Bence-Jones Myeloma with Pleural Effusion; Response to α-Interferon and Combined Chemotherapy

Abstract

A 73-year-old female patient with myelomatous pleural effusions is described. She was admitted to our hospital with lumbago and emaciation. Laboratory findings revealed cytopenia and hypogammaglobulinemia. Immunoelectrophoresis demonstrated Bence-Jones monoclonal protein in the serum, but not in the urine. Bence-Jones myeloma was diagnosed by the bone marrow aspiration. Chest X-ray film, however, showed bilateral pleural effusions. Fluid cytology revealed numerous immature plasma cells, indicating pleural involvement. Intrapleural administration of α-interferon combined with systemic chemotherapy (oral melphalan-prednisolone with α-interferon im.) was successful in maintaining the resolution of pleural effusions. Intrapleural α-interferon administration seems to be effective in the management of myelomatous pleural effusions. © 1992, The Japanese Society of Internal Medicine. All rights reserved.