Synthesis, Characterization and Biological Activity of Transition Metal Complexes of [1-(2-bromo, 5-methoxy benzylidene) hydrazine] Ligand

Abstract

A series of metal complexes was synthesized from the novel Schiff base [1-(2-bromo-5-methoxybenzylidene)-hydrazine] ligand. The ligand and metal complexes were well characterized by spectroscopic methods. The ligand was found to be monodentate. Stoichiometry of the ligand to metal ions was confirmed to be 4:1. Furthermore, the synthesized metal complexes were screened for antimicrobial, antitubercular, and antimalarial activities, which revealed that Cu (II) and Zn (II) showed excellent antimicrobial activity, Ni (II) was active against M. Tuberculosis, and Cd (II) showed excellent antimalarial activity.