Confocal microscopy during voltage-clamp depolarization of mammalian heart cells revealed distinct local [Ca2+](i)-transients that resulted from Ca2+ released through sarcoplasmic reticulum (SR) release channel(s). When voltage was varied, the latency to occurrence and the relative probability of local [Ca2+](i)-transients varied as predicted if SR Ca2+-release is linked tightly to Ca2+ flux through co-associated L-type Ca2+-channels.
CITATION STYLE
Wier, W. G., Strauss, H., Morad, M., Barry, W., & Ter Keurs, H. E. D. J. (1995). Confocal microscopy reveals local SR calcium release in voltage-clamped cardiac cells. In Advances in Experimental Medicine and Biology (Vol. 382, pp. 81–88). Springer New York LLC. https://doi.org/10.1007/978-1-4615-1893-8_9
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