Five polymorphic index markers were analyzed by polymerase chain reaction (PCR) to ascertain the parental origin of the extra X chromosomes in seven polysomic cases (one 49,XXXXX, three 49,XXXXY, two 48,XXXY, and one 48, XXYY). All four X chromosomes in 49, X polysomies were maternal in origin and the extra X chromosomes in 48 X polysomies were paternal. In each case the multiple X chromosomes were contributed by a single parent. Taken together with previously reported cases, these data support a single mechanism of sequential nondisjunction during either maternal or paternal gametogenesis as the cause of higher order sex chromosome polysomy. © 1994 Springer-Verlag.
CITATION STYLE
Leal, C. A., Belmont, J. W., Nachtman, R., Cantu, J. M., & Medina, C. (1994). Parental origin of the extra chromosomes in polysomy X. Human Genetics, 94(4), 423–426. https://doi.org/10.1007/BF00201605
Mendeley helps you to discover research relevant for your work.