The polarized effect of intracellular calcium on the renal epithelial sodium channel occurs as a result of subcellular calcium signaling domains maintained by mitochondria

Abstract

Background: Mitochondria can sequester calcium and regulate signaling processes in epithelia. Results: Intracellular calcium regulates the renal epithelial sodium channel in a polarized fashion, and this polarity is dependent on mitochondrial calcium uptake. Conclusion: Mitochondria maintain calcium polarity in renal epithelia. Significance: Identifying subcellular calcium signaling domains in renal epithelia is essential to understanding ion channel regulation.