Hepatoprotective activity of the biherbal extract in carbon tetrachloride (CCl4) Induced Hepatoxicity—A Study of Histopathological Image Analysis

Abstract

Hepatotoxicity implies chemical-driven liver damage. Liver disease is still a worldwide health problem. Traditional drugs for the treatment of liver diseases are at times inactive and can have adverse effects. So there is a worldwide trend to go back to traditional medicinal plants. The present investigation was aimed for a comparative study of conventional histopathological examination with modern electronic image processing studies with respect to evaluating the hepatoprotective action of ethanolic extract of Melia azedarach (MAE) and Piper longum (PLE) with their combination biherbal extract (BHE) against carbon tetrachloride (CCl4) induced hepatic damage in rats. The three ethanolic extracts at a dose level of 50 mg/kg body weight each were administered to three different groups of rats orally once daily for 14 days. The hepatoprotective effect of the biherbal extract (BHE) was assessed by histopathological photograph of the cells.