Correlates of Subjective and Mild Cognitive Impairment: Depressive Symptoms and CSF Biomarkers

  • Grambaite R
  • Hessen E
  • Auning E
  • et al.
N/ACitations
Citations of this article
59Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Aims: To improve early diagnosis of dementia disease, this study investigates correlates of cognitive complaints and cognitive test performance in patients with subjective (SCI) and mild (MCI) cognitive impairment. Methods: Seventy patients from a memory clinic, aged 45-79, with a score of 2 (n = 23) or 3 (n = 47) on the Global Deterioration Scale, were included. CSF biomarkers [Aβ 42, total tau (T-tau) and phosphorylated tau (P-tau)], depressive symptoms, cognitive performance, and complaints were examined. Results: Correlation analysis showed that cognitive complaints increased with decreasing cognitive performance in SCI and decreased with decreasing performance in MCI. Linear regression models revealed that cognitive complaints were associated with depressive symptoms in both groups of patients, while cognitive performance was associated with CSF Aβ 42 and P-tau in SCI and with T-tau and P-tau in MCI. Conclusion: These results suggest that depressive symptoms are associated with cognitive complaints, while degenerative changes are associated with objective cognitive decline in high-risk predementia states.

Cite

CITATION STYLE

APA

Grambaite, R., Hessen, E., Auning, E., Aarsland, D., Selnes, P., & Fladby, T. (2013). Correlates of Subjective and Mild Cognitive Impairment: Depressive Symptoms and CSF Biomarkers. Dementia and Geriatric Cognitive Disorders Extra, 3(1), 291–300. https://doi.org/10.1159/000354188

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free