LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. The lectin is specific for α-galactose present on glycosphingolipids of the globoside family and has therefore been proposed to play a role in cell adhesion and in internalization of bacteria in epithelial cells. The lectin has also direct toxic activity. Search for high-affinity inhibitors can be performed on the recombinant lectin, with use of surface plasmon resonance assays and structural studies.
CITATION STYLE
Kuhaudomlarp, S., Gillon, E., Varrot, A., & Imberty, A. (2020). LecA (PA-IL): A galactose-binding lectin from pseudomonas aeruginosa. In Methods in Molecular Biology (Vol. 2132, pp. 257–266). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0430-4_25
Mendeley helps you to discover research relevant for your work.