The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis. © 2010 Springer Basel AG.
CITATION STYLE
Carosella, E. D., Gregori, S., Rouas-Freiss, N., Lemaoult, J., Menier, C., & Favier, B. (2011). The role of HLA-G in immunity and hematopoiesis. Cellular and Molecular Life Sciences, 68(3), 353–368. https://doi.org/10.1007/s00018-010-0579-0
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