Lp(a) Lipoprotein, Vascular Disease, and Mortality in the Elderly

  • Ariyo A
  • Thach C
  • Tracy R
239Citations
Citations of this article
91Readers
Mendeley users who have this article in their library.

Abstract

Background As compared with what is known about predictors of vascular events in middle-aged persons, less is known about these events in the elderly. Lp(a) lipoprotein, which plays an important part in atherothrombogenesis, has been associated with an increased risk of vascular disease. We investigated this relation among older U.S. adults. Methods In a prospective study of 5888 community-dwelling older adults (65 years of age or older) in the United States, 2375 women and 1597 men who were free of vascular disease provided base-line serum samples for analysis for levels of Lp(a) lipoprotein. These 3972 subjects were followed for a median of 7.4 years to evaluate the development of stroke and to track deaths from vascular causes and all causes. The men and women were divided into quintile groups according to the Lp(a) lipoprotein level at base line. Results Using Cox proportional-hazards models, we determined the risk associated with each quintile level of Lp(a) lipoprotein, with the lowest quintile serv...

Cite

CITATION STYLE

APA

Ariyo, A. A., Thach, C., & Tracy, R. (2003). Lp(a) Lipoprotein, Vascular Disease, and Mortality in the Elderly. New England Journal of Medicine, 349(22), 2108–2115. https://doi.org/10.1056/nejmoa001066

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free