How does lithium mediate its therapeutic effects?

8Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

For the psychiatrist, lithium is an effective drug for both the treatment and prophylaxis of bipolar disorder. The molecular mechanisms underlying its therapeutic actions have not yet been fully explained. The effects of lithium on a number of enzymes and biological processes have been studied. Inositol monophosphatase and glycogen synthase kinase-3 (GSK-3) have been suggested as the relevant intracellular targets for lithium action. The discovery of the role of GSK-3, the Wnt signalling system, and the anti-apoptotic factor Bcl-2 has led to the suggestion that there could be a therapeutic use for lithium in neurodegenerative disorders, such as Alzheimer's disease.

Cite

CITATION STYLE

APA

Strunecká, A., Patočka, J., & Šárek, M. (2005). How does lithium mediate its therapeutic effects? Journal of Applied Biomedicine. University of South Bohemia in Ceske Budejovice Faculty of Health and Social Sciences. https://doi.org/10.32725/jab.2005.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free