Polymeric micelles

Abstract

The block copolymers composed of two kinds of polymers with different properties self-assemble into core-shell type nanoparticles, so-called polymer micelles. Polymeric micelles are formed by various driving forces such as hydrophobic interactions, electrostatic interactions, metal complex formation. Polymeric micelles are useful as a drug delivery system (DDS) because they can stably encapsulate a variety of compounds and can control release of these molecules. In addition, polymeric micelles are known to efficiently accumulate in solid cancers after systemic administration, thereby enhancing the efficacy and reducing the side effects of anticancer agents. Indeed, several micellar formulations of anticancer agents have progressed to clinical trials. This article outlines polymer micelle from the viewpoint of formulation and particle design.