T-cell development and differentiation is coordinated by a multitude of signaling molecules and transcription factors that impart distinct functional properties to progenitors. In this review, we focus on the role of the T lineage-enriched chromatin organizer and regulator SATB1 in T-cell differentiation. SATB1 mediates Wnt signaling by recruiting β-catenin to its genomic targets and coordinates T helper type 2 (TH2) differentiation by positively regulating GATA-3. In contrast, maintenance of regulatory T cell (Treg) functions are dependent on inhibition of SATB1-mediated modulation of global chromatin organization. We discuss how regulation of the activity of SATB1 has a critical role in driving these two important differentiation pathways in T cells. © 2012 Australasian Society for Immunology Inc. All rights reserved.
CITATION STYLE
Burute, M., Gottimukkala, K., & Galande, S. (2012, October). Chromatin organizer SATB1 is an important determinant of T-cell differentiation. Immunology and Cell Biology. https://doi.org/10.1038/icb.2012.28
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