Prospective observational cohort study of Health Related Quality of Life (HRQOL), chronic foot problems and their determinants in gout: A research protocol

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Abstract

Background: Gout is the commonest inflammatory arthritis affecting around 1.4% of adults in Europe. It is predominantly managed in primary care and classically affects the joints of the foot, particularly the first metatarsophalangeal joint. Gout related factors (including disease characteristics and treatment) as well as comorbid chronic disease are associated with poor Health Related Quality of Life (HRQOL) yet to date there is limited evidence concerning gout in a community setting. Existing epidemiological studies are limited by their cross-sectional design, selection of secondary care patients with atypical disease and the use of generic tools to measure HRQOL. This 3year primary care-based prospective observational cohort study will describe the spectrum of HRQOL in community dwelling patients with gout, associated factors, predictors of poor outcome, and prevalence and incidence of foot problems in gout patients. Methods. Adults aged18years diagnosed with gout or prescribed colchicine or allopurinol in the preceding 2years will be identified through Read codes and mailed a series of self-completion postal questionnaires over a 3-year period. Consenting participants will have their general practice medical records reviewed. Discussion. This is the first prospective cohort study of HRQOL in patients with gout in primary care in the UK. The combination of survey data and medical record review will allow an in-depth understanding of factors that are associated with and lead to poor HRQOL and foot problems in gout. Identification of these factors will improve the management of this prevalent, yet under-treated, condition in primary care. © 2012 Chandratre et al.; licensee BioMed Central Ltd.

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Chandratre, P., Mallen, C., Richardson, J., Rome, K., Bailey, J., Gill, R., … Roddy, E. (2012). Prospective observational cohort study of Health Related Quality of Life (HRQOL), chronic foot problems and their determinants in gout: A research protocol. BMC Musculoskeletal Disorders, 13. https://doi.org/10.1186/1471-2474-13-219

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