Targeting tumours with radiolabeled antibodies

Abstract

The introduction of radiolabelled antibodies targeting the lymphocyte antigen CD20 in certain hematologic malignancies received positive attention and is now accepted as a treatment modality. Treating solid tumours with radiolabelled antibodies has, so far, not been met with the same appreciation and such therapy for the large groups of malignancies like colorectal, breast, prostate, ovarian, lung cancer and brain tumours still require improvements in order to gain acceptance. In this chapter limitations, possibilities and future directions to improve therapy with radiolabelled antibodies are discussed. © 2008 Springer Science+Business Media B.V.