MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

  • Nešić D
  • Vukmanović S
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Abstract

MHC molecules influence the fate of T lymphocytes at two important stages of their differentiation. Recognition of self peptide/MHC complexes in the thymus determines whether immature T cells should live and mature into immunocompetent T cells or whether they should die. In the periphery, recognition of Ags presented by MHC molecules induces T cell activation, proliferation, and differentiation into effector/memory T cells. We describe in this work a third role that MHC molecules play in T cell physiology. CD8+ thymic emigrants require presence of MHC class I molecules in the periphery to seed the peripheral lymphoid organs. Numbers of CD8+ T cells are reduced severely in both the thymus and the periphery of β2-microglobulin-deficient (β2m−/−) mice. When grafted with wild-type (β2m+/+) thymic epithelium, immature β2m−/− T cells that populate the graft develop into functional mature CD8+ cells. However, significant numbers of peripheral CD8+ cells in grafted β2m−/− mice can be observed only after injection of MHC class I-expressing cells in the periphery. Thus, naive T cells in the periphery do not passively await antigenic stimulation, but actively engage in interactions with self MHC molecules that may promote their survival.

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Nešić, D., & Vukmanović, S. (1998). MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants. The Journal of Immunology, 160(8), 3705–3712. https://doi.org/10.4049/jimmunol.160.8.3705

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