MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants

  • Nešić D
  • Vukmanović S
105Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

Abstract

MHC molecules influence the fate of T lymphocytes at two important stages of their differentiation. Recognition of self peptide/MHC complexes in the thymus determines whether immature T cells should live and mature into immunocompetent T cells or whether they should die. In the periphery, recognition of Ags presented by MHC molecules induces T cell activation, proliferation, and differentiation into effector/memory T cells. We describe in this work a third role that MHC molecules play in T cell physiology. CD8+ thymic emigrants require presence of MHC class I molecules in the periphery to seed the peripheral lymphoid organs. Numbers of CD8+ T cells are reduced severely in both the thymus and the periphery of β2-microglobulin-deficient (β2m−/−) mice. When grafted with wild-type (β2m+/+) thymic epithelium, immature β2m−/− T cells that populate the graft develop into functional mature CD8+ cells. However, significant numbers of peripheral CD8+ cells in grafted β2m−/− mice can be observed only after injection of MHC class I-expressing cells in the periphery. Thus, naive T cells in the periphery do not passively await antigenic stimulation, but actively engage in interactions with self MHC molecules that may promote their survival.

References Powered by Scopus

T cell receptor antagonist peptides induce positive selection

2433Citations
N/AReaders
Get full text

Induction of apoptosis in mature T cells by tumour necrosis factor

1065Citations
N/AReaders
Get full text

β2-Microglobulin deficient mice lack CD4<sup>-</sup>8<sup>+</sup> cytolytic T cells

994Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

1386Citations
N/AReaders
Get full text

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

820Citations
N/AReaders
Get full text

Selecting and maintaining a diverse T-cell repertoire

734Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Nešić, D., & Vukmanović, S. (1998). MHC Class I Is Required for Peripheral Accumulation of CD8+ Thymic Emigrants. The Journal of Immunology, 160(8), 3705–3712. https://doi.org/10.4049/jimmunol.160.8.3705

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

64%

Researcher 5

23%

Professor / Associate Prof. 3

14%

Readers' Discipline

Tooltip

Immunology and Microbiology 9

43%

Agricultural and Biological Sciences 7

33%

Biochemistry, Genetics and Molecular Bi... 3

14%

Medicine and Dentistry 2

10%

Save time finding and organizing research with Mendeley

Sign up for free