This review describes a selection of macrocyclic natural products and structurally modified analogs containing peptidic and non-peptidic elements as structural features that potentially modulate cellular permeability. Examples range from exclusively peptidic structures like cyclosporin A or phepropeptins to compounds with mostly non-peptidic character, such as telomestatin or largazole. Furthermore, semisynthetic approaches and synthesis platforms to generate general and focused libraries of compounds at the interface of cyclic peptides and non-peptidic macrocycles are discussed.
CITATION STYLE
Ermert, P., Luther, A., Zbinden, P., & Obrecht, D. (2019). Frontier Between Cyclic Peptides and Macrocycles. In Methods in Molecular Biology (Vol. 2001, pp. 147–202). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9504-2_9
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